EXECUTIVE
HEALTHEXECUTIVE
HEALTHPRECISION.
PREVENTION.
LONGEVITY.

THE MOST ADVANCED MEDICAL TECHNOLOGY

THE CORNERSTONE OF LONGEVITY

Longevity Medicine is a field that focuses on prevention, reversal, and/or delay of age-related diseases. People are living longer but that does not mean they are living healthier. In fact, it is estimated that six in ten Americans live with at least one chronic disease. Our executive longevity programs focus on utilizing the most advanced medical technologies and modalities to optimize an individuals healthspan to then extend their lifespan.

EXTEND

Extend your healthspan by preventing and addressing age-related conditions with advanced medical strategies.

ENHANCE

Enhance your well-being through personalized, cutting-edge treatments tailored to your unique biology.

EXCEL

Excel in life with optimized vitality and resilience, empowering you to thrive at any age because why should age stop you?

What is an Executive Physical?

An “Executive Physical” is a term that is used to describe a comprehensive health assessment that goes above and beyond what is typically included in a regular physical exam. The term originates from the corporate world, where company executives often require a more comprehensive approach to managing their health due to their unique and demanding lifestyle.

SCHEDULE A CONSULT

OUR REVOLUTIONARY PROGRAMS

THE PHYSICAL EXAM OF THE FUTURE

The Executive Physical is a cornerstone of our longevity programs, utilizing cutting-edge technology and comprehensive testing to assess your health. At the Institute for Human Optimization, we go further with a multi-omic precision medicine approach, crafting personalized plans based on the latest scientific advancements.

ADVANCED IMAGNG ADD-ONS

COMPREHENSIVE MEDICAL HISTORY REVIEW

BIOLOGICAL BASELINE & AUDIT

BODY COMPOSITION TESTING

PERFORMANCE TESTING

MEMORY & COGNITIVE HEALTH TESTING

HEALTH & VITALITY TESTING

CARDIOMETABOLIC TESTING

MULTI-OMIC TESTING

EARLY CANCER DETECTION

DECODING WELLNESS

THE COMPREHENSIVE BIOLOGICAL AUDIT EXPERIENCE

We go beyond early disease detection to show you how to avoid diseases before they start.   Our comprehensive BIOLOGICAL AUDIT is an exclusive program that unites the potential of leading diagnostics and exceptional clinicians just for you. Our program commences with a thorough range of advanced tests that establish your individual baseline. We then implement state-of-the-art diagnostics and precision longevity care to help you achieve your peak performance, both now and in the future. Get ready to take a leap towards longevity with The Institute for Human Optimizations’ innovative approach to individualized medicine.

  • FULL BODY MRI

     

    Our non-invasive MRI uses AI to detect abnormalities, accurately screen for cancer, and analyze brain patterns for early signs of neurodegenerative diseases.

  • CTA AI IMAGING

     

    AI-powered CTA detects early heart disease risks by spotting rupture-prone soft plaques, empowering preventive action.

  • GENOMIC ANALYSIS

     

    Unlock your DNA’s secrets with our AI-driven Genomic Analysis, revealing risks and personalized health recommendations for optimal well-being.

  • EARLY CANCER SCREENING

     

    Detect cancer early with our blood test, screening for 50+ types, including those without regular tests, to catch it before it spreads.

  • BIOLOGICAL AGE TESTING

     

    Biological age reflects your true health, assessed through epigenetic testing of DNA markers to predict lifespan and health span.

  • ADVANCED BIOMARKER ANALYSIS

     

    Comprehensive bloodwork to assess kidney, liver, hormones, vitamins, minerals, lipids, and glucose, helping identify risks and optimize health with personalized recommendations.

  • MICROBIOME TESTING

     

    We’ll analyze your gut microbiome using the latest science to create a personalized plan, identifying imbalances or issues affecting digestion, absorption, inflammation, and immune function

  • METABOLOMICS

     

    Metabolomics analyzes your body’s metabolic profile to optimize health by identifying biomarkers and metabolic imbalances.

Executive Health Program: What’s Included?

Our Executive Health Program has helped 35% of clients detect diseases early, including aneurysms, tumors, liver and pancreatic cancers, and heart disease—empowering proactive health management.

  • 1

    Total Wellness Package

    Our comprehensive wellness package includes a series of tests and screenings to give you a complete view of your health, empowering you to make informed decisions for a longer, healthier life:

    • Total Baseline Test
    • Food Sensitivity Test
    • Micronutrient Test
    • Wheat Zoomer (Sensitivity) Test
    • 3×4 Genetic Blueprint Test
    • Total Tox Burden Package
  • 2

    TruAge Epigenetic Test

    Discover your true biological age, a powerful predictor of chronic disease, by testing your epigenetic age and identifying risk factors.

  • 3

    Full-Body MRI & Chest CT

    Catch early signs of cancer, diseases, and anatomical abnormalities long before they are detected by traditional methods.

  • 4

    CT Calcium Score

    Assess your heart attack risk through a preventative screening, allowing you to address and optimize your heart health. Highly recommended for individuals with a family history of heart disease or other risk factors such as high blood pressure, high LDL cholesterol, diabetes, smoking, obesity, or physical inactivity.

  • 5

    Complete Medical & Physical Wellness Plan

    A thorough physical exam and InBody scan, followed by a detailed review and personalized health optimization plan with a medical professional.

  • 6

    Quarterly Baseline & Follow-Up

    Stay on track with quarterly tests and follow-up appointments to ensure you’re making progress toward your longevity goals. Contact us today for a consultation.

CRACK THE CODE OF AGING

THE 12 HALLMARKS OF AGING

Fundamentally, aging is a cellular process. On a biological level, aging can be thought of as the accumulation of cellular damage and deterioration over time, which leads to impaired cellular function. This deterioration is the chief risk factor for almost all diseases, including diabetes, cardiovascular disease, cancer, and neurodegenerative disease, among others.What causes this deterioration? Humans have spent millennia trying to figure this out.

These hallmarks of aging are interconnected and often reinforce each other, leading to a gradual decline in cellular and organismal function over time. When the decline of our tissues (our biological age) outpaces our actual age in years (chronological age), we may actually experience accelerated aging. Managing this balance is critical to feeling healthier for longer.

Aging isn’t just about years; the 12 hallmarks show us how to live longer, healthier, and more vibrant lives.

GENOMIC INSTABILITY TELOMERE ATTRITIONEPIGENETIC ALTERATIONLOSS OF PROTEOSTASIS DISABLED MACROAUTOPHAGYDEREGULATED NUTRIENT SENSINGMITOCHONDRIAL DYSFUNCTIONCELLULAR SENESCENSE STEM CELL EXHAUSTIONALTERED INTERCELLULAR COMMUNICATIONCHRONIC INFLAMMATIONDYSBIOSIS

Hallmark #1: Genomic Instability – Your genome is your complete set of genetic instructions. Genomic instability is the process of damage to DNA that accumulates over time. Toxins, DNA replication errors, and oxidative stress all contribute to genomic instability, which can cause cell mutations and lead to diseases like cancer. A healthy diet in conjunction with intermittent fasting will help limit genomic instabilities by limiting exposure to toxins while also increasing transcriptional fidelity during cellular division (protein synthesis). Exercise has a similar effect; it increases mitochondrial function, resulting in increased energy production, as well as reduces levels of reactive oxygen species that cause further genome damage.

Hallmark #2: Telomere Attrition – Telomeres are essentially the caps on the end of chromosomes that protect them from deterioration and damage. Our natural DNA replication mechanisms do not duplicate all the telomeres when each cell divides, so each chromosome has fewer telomeres. Once the telomeres run out, you hit what’s called a cell growth arrest. This means you are limited to how much new tissue you can regenerate as you age. Exercise is one activity that extends your telomeres (Semeraro, 2020). To understand how telomeres are preserved, think of the plastic tips on the ends of your shoelaces. Every time you use it to tie your shoes and then untie them again, that little cap gets a bit shorter. If these caps get too short or fray off completely before they can be replaced by naturally occurring DNA replication mechanisms during cell division in each chromosome, there will come an age where cells may no longer divide enough times for natural tissue regeneration because you have hit & cell growth arrest. This means you won’t be able to replace old tissues with new ones as well anymore! One way this is avoided by preserving our telomeres is via physical activity like running, which prevents wear-and-tear damage otherwise caused by oxidation and free radicals.

Hallmark #3: Epigenetic Alterations – All of the DNA in the cells throughout the body is exactly the same. So, to create different types of body tissue, your DNA has to be modified with epigenetic information. Therefore, skin tissue is different from brain tissue, and so on. Epigenetic information suppresses or enhances the expression of particular lines of genetic code. Aging can cause problems with the epigenetic code, which alters gene expression and affects cellular function. Within the immune system, this could cause the body to become vulnerable to certain pathogens. Research shows that epigenetic alterations can be slowed down by including plenty of bioactive compounds in your diet, known as phytonutrients (Meeran et al., 2010). You can do this by consuming healthy fruits, vegetables, seeds, nuts, and oils that can be tailored to your individual DNA in a fascinating emerging field of nutrigenomics.

Hallmark #4: Loss of Proteostasis – Think of proteins as raw materials that must be refined and shaped into usable building blocks. Inside your cells, proteins are continually being degraded and synthesized. This process is called proteostasis or protein homeostasis. As proteins are being folded and shaped, various mechanisms are set in place to better stabilize and restore properly folded proteins and degrade improperly shaped proteins. Without these mechanisms, proteins will accumulate and cause damage to a cell. Over time, the stabilizing and restoring mechanisms become less efficient, which can damage protein components. This leads to a higher risk of diseases such as Alzheimer’s (Katewa and Kapahi, 2010). Research shows that restricting
calories and practicing intermittent fasting can help increase the efficiency of the protein-stabilizing and restoring components (Matai et al., 2019). In addition, dietary restriction improves proteostasis and increases life span through endoplasmic reticulum hormesis (Proceedings of the National Academy of Sciences, n.d.).

Hallmark #5: Disabled Macroautophagy – Macroautophagy (or simply “autophagy”) is vital for cellular housekeeping. During the process of autophagy, damaged cytoplasmic material is separated into two-membrane vesicles called “autophagosomes” for disposal. The process is driven by genes and proteins that are also deeply important to alternative degradation processes. For example, intracellular waste (see dysfunctional mitochondria) can have a domino effect on the efficiency of a suite of other bodily processes. As we age, our body’s efficiency in autophagy decreases, meaning if autophagy is inhibited, we will age faster. And the faster we physiologically age, the more inhibited autophagy becomes. The reverse is also true: autophagy stimulation can decelerate aging, and some studies on mice even show that it can be partially reversible. Supporting autophagy can even reduce age-associated pathologies.

Hallmark #6: Deregulated Nutrient-Sensing – Our body interacts and detects the nutrients we consume through a complex network of extracellular ligands (like insulins and IGFs) and signaling. These signals can kick off a domino effect of cellular processes. This gives nutrient-sensing an immense amount of regulatory power over cellular activity, including autophagy, protein synthesis, metabolism, and other core functions. This signaling pathway relies on a network of receptors. Even drugs targeting diseases like cancer and metabolic disorders must engage this network to have a chance at successfully treating the disease. For this reason and others, the nutrient-sensing network could be a viable means of reverting age-related immunosenescence (reduced immune system resiliency).

Hallmark #7: Mitochondrial Dysfunction – Your mitochondria are the powerhouses of your cells. During the production of energy, mitochondria can become dysfunctional and form free radicals. While small amounts of free radicals have important roles in the body, high amounts can cause serious damage to the cell. The problem is free radicals trigger mitochondrial dysfunction by causing mitochondrial DNA mutations. In turn, this causes even more free radicals — it’s a vicious cycle. An overabundance of free radicals causes oxidative stress, contributing to every age-related disease. Exercise, intermittent fasting, and avoiding processed and refined carbohydrates help prevent mitochondrial dysfunction and reduce free radical
damage.

Hallmark #8: Cellular Senescence – When your cells have had more than enough DNA damage, stress, and telomere shortening, they enter a state of growth arrest known as cellular senescence. This function is put in place to prevent damaged cells from turning into cancerous cells. However, in the process, it also stops allowing worn-out tissue to be replenished and rebuilt. Senescent cells often secrete inflammatory molecules that further damage the cellular environment, leading to chronic inflammatory conditions, including heart disease and osteoarthritis. Several plant-based compounds, including quercetin and berberine, are known to flush these cells out of the body

Hallmark #9: Stem Cell Exhaustion – As you age, your ability to recover from injury sharply declines because your stem cells lose their capacity to replenish damaged tissue. Stem cells spend the majority of their time dormant. But as your body activates them to heal injuries, they become vulnerable to telomere shortening, cellular senescence, and DNA damage. As time goeSon, this eventually leads to the exhaustion of stem cells. A healthy diet, adequate sleep, stress reduction, and exercise can help slow down stem cell exhaustion.

Hallmark #10: Altered Intercellular Communication – Your cells must transfer information back and forth to grow and function. They secrete signaling molecules to the surrounding cells and send molecular messengers through your bloodstream to faraway cells. As you age, your cells’ ability to both send and receive this bit of information diminishes. This dysfunctional cell- to-cell signaling leads to numerous issues, including immune system failure, chronic inflammation, and the inability to recognize and eliminate pathogens and cancer cells. Exercise is associated with improved intercellular communication.

Hallmark #11: Chronic Inflammation — As inflammation increases with age (also known as “inflammaging”), it is evidenced by an elevated circulation of cytokines and biomarkers (like CRP) as well as predictive markers in plasma. Inflammation negatively affects major systems in the body, ranging from neuroinflammation to intervertebral disc degeneration. Inflammaging can also worsen defective immunosurveillance, loss of self-tolerance, and overexpression of pro- inflammatory proteins. Essentially, the body is in a state of increasing hyper-reactivity to triggers. Whether age-related or chronic, this amplifies other burdens on the body, reduces resiliency, and accelerates aging. Because inflammation is also closely linked to other hallmarks of aging, anti-inflammatory interventions may prove to be extremely beneficial as an anti-aging strategy.

Hallmark #12: Dysbiosis – Gut microbiota-induced inflammaging can occur with chronic systemic inflammation. Dysbiosis occurs when the bacteria-host bidirectional communication is disrupted. Microbiota changes in aging can trigger a decline in adaptive immunity, which can leave individuals vulnerable to age-related diseases. Findings not only suggest strong causal links between aging and dysbiosis but that there may be multiple gut-microbiome trajectories in aging. To mitigate the effects of dysbiosis, scientists are exploring interventions (such as probiotics or fecal transplants) in hopes of recolonizing and restoring a youthful gut microbiome.

OPTIMIZE YOUR HEALTH WITH EXECUTIVE-LEVEL CARE

ADVANCED HEALTH STRATEGIES TO MATCH YOUR AMBITION

At the Institute for Human Optimization, we have curated and partnered with the latest state-of-the-art technologies to create our most proactive longevity programs available. We utilize in-depth diagnostic tools that can identify risks before symptoms occur. By understanding the hallmarks that represent common denominators of aging, we can leverage that data and its relative contribution to aging, to then identify targets to improve human health during aging.

Our Executive Longevity Programs are best suited for individuals over 40 who are invested in their optimal health, performance, vitality, and longevity.

FAQ about our Executive Longevity Programs

Our Executive Longevity Programs begin at $16,200 with different programs to customize exactly what fits your health and wellness needs

Yes! All of our Executive Longevity Program patients receive a discount on all of our other services/programs.

Precision Medicine focuses on identifying biomarkers, which are defined as biological characteristics or features that can be used to identify a disease state, diagnose a condition or predict an outcome. These biomarkers are being studied in detail to identify genetic factors that may influence responses to drugs, treatments, lifestyle, and environmental factors. This type of individualized medicine is seen as the future of healthcare. You can learn more about Precision Medicine HERE.

The Institute for Human Optimization (IfHO) is a private-pay practice and a non-Medicare provider. Appointments with our physicians are not billed through insurance. IfHO does not accept insurance or Medicare, and we do not file insurance paperwork on your behalf. At your request, we can provide you with a receipt for services (Super bill) , which you may submit to your insurance plan for reimbursement. However, IfHO does not guarantee reimbursement.

Lab testing is included in the cost of our Executive Longevity Physical Programs.

We are able to do your blood draw at your appointment. We are also partnered with LabCorp. 

Currently, we are only accepting 100 additional new patients per year. This allows us to scale our practice comfortably, prioritize patient care, continuously improve and optimize our programs to match the latest research and science.

Yes! However, our Executive Physical requires in-person evaluation for the initial exam components. We are conveniently located in Maryland near BWI Airport (15 minutes), DCA (45 minutes), and IAD (~1 Hour and 15 minutes).

Click here to set up your  complimentary Discovery Call or send us an email at Support@IFHO.Org

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